[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Base Information

Chemical Name:[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate
CAS No.:1280665-78-2
Molecular Formula:C₃₈H₅₁N₇O₉
Molecular Weight:749.864
Hs Code.:

[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Synonyms:[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

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Chemical Property of [(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of [(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

There total 14 articles about [(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1165952-92-0
cyclohexa-1,4-diene

: 1280665-78-2
[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / Inert atmosphere

2: sodium azide; ammonium chloride / water; methanol / 2 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / Inert atmosphere

4: ammonia / ethanol; water / 16 h / 20 - 30 °C / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 3 h / Inert atmosphere

6: pyridine / 3 h / Inert atmosphere

7: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 - 30 °C

8: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With pyridine; sodium azide; ammonia; hydrogen; sodium hydrogencarbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 620604-44-6
methyl 7-nitrobenzofuran-4-carboxylate

: 1280665-78-2
[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 - 30 °C / 2280.15 Torr / Cooling with ice

2.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 6 h / Reflux; Inert atmosphere

3.1: water; lithium hydroxide / methanol / 3 h / Reflux; Inert atmosphere

3.2: pH 2

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In methanol; Methyl isobutyl carbinol; dichloromethane;

Reference yield:

: 1010702-81-4
(1R,2R,4R,5R)-2-amino-5-azido-cyclohexane-1,4-diol

: 1280665-78-2
[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 3 h / Inert atmosphere

2: pyridine / 3 h / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 - 30 °C

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With pyridine; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane;