phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate

Base Information

• Chemical Name: phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate
• CAS No.: 1422511-05-4
• Molecular Formula: C₄₅H₆₂ClFN₆O₇Si₂
• Molecular Weight: 909.646

Synonyms:phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate

Chemical Property of phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate

There total 19 articles about phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl ((3R,7S)-7-(((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)amino)-3-methyl-2-oxo-9-((2-(trimethylsilyl)ethoxy)methyl)-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecin-14-yl)carbamate → phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-14-yl)carbamate (1422511-05-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-14-yl)carbamate (1422511-05-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 1 h / 0 °C

2.1: zinc; ammonium chloride / methanol / 4 h / 60 °C / Sealed tube

3.1: triethylamine / ethyl acetate / 0.5 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 0.67 h / 40 °C / Inert atmosphere

4.2: 40 °C / Inert atmosphere

5.1: hydrogen; palladium on activated charcoal / methanol / 20 °C / Inert atmosphere

6.1: lithium hydroxide; water / methanol / 1 h / 60 °C

7.1: dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 96 h / 20 - 50 °C

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

9.1: sodium cyanoborohydride / methanol / 2 h

9.2: 0.25 h

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

With dmap; palladium on activated charcoal; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-chloro-3-fluoro-2-formylpyridine (1260878-78-1) → phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-14-yl)carbamate (1422511-05-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran; pentane / 1.33 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: dmap; 1H-imidazole / 12 h / 20 °C

3.1: osmium(VIII) oxide; sodium periodate / methanol; water / 2 h / 20 °C

4.1: sodium cyanoborohydride / methanol / 2 h

4.2: 0.25 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

With 1H-imidazole; dmap; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; sodium cyanoborohydride; In tetrahydrofuran; methanol; water; pentane;

upstream raw materials:

4-chloro-3-fluoro-2-formylpyridine

(R)-1-(4-chloro-3-fluoropyridin-2-yl)but-3-en-1-ol

(R)-2-(1-((tert-butyldimethylsilyl)oxy)but-3-en-1-yl)-4-chloro-3-fluoropyridine

(R)-3-((tert-butyldimethylsilyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propanal

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1422511-05-4 phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send