1260878-78-1

Basic information

• Product Name: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE
• Synonyms: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE;4-chloro-3-fluoropicolinaldehyde
• CAS NO: 1260878-78-1
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.5455232
• Mol File: 1260878-78-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 196.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.444±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.69±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(1260878-78-1)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(1260878-78-1)

Safety Data

• Hazardous Substances Data: 1260878-78-1(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is a chemical compound with the molecular formula C6H3ClFNO. It is a yellow to brown liquid with a molecular weight of 161.54 g/mol. 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is a highly reactive aldehyde with a pyridine ring, making it useful in organic synthesis for the formation of various heterocyclic compounds. 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is also known for its potential use as a building block in the development of new pharmaceutical agents, particularly in the field of medicinal chemistry. 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE should be handled with caution due to its reactivity and potential health hazards.

Upstream product

• 2546-56-7 4-chloro-3-fluoro-pyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 399-88-2 3-fluoro-4-methylpyridine 
• 91837-43-3 1,3-dioxoisoindolin-2-yl (tert-butoxycarbonyl)glycinate 
• 109-72-8 n-butyllithium 

Downstream Products

• 1422511-05-4 phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate 
• 1422510-25-5 (S)-phenyl (1-(4-chloro-3-fluoropyridin-2-yl)-3-oxopropyl)carbamate 
• 1422510-27-7 (S)-phenyl (1-(4-chloro-3-fluoropyridin-2-yl)but-3-en-1-yl)carbamate 

Relevant articles and documents

HETEROARYL PLASMA KALLIKREIN INHIBITORS

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Regioselective amidomethylation of 4-chloro-3-fluoropyridine by metalation and minisci-type reactions

The synthesis of a series of 2-amidomethylated pyridines (3-8) was investigated, starting from 4-chloro-3- fluoropyridine. Kinetic deprotonation at -75 °C followed by reaction with DMF gave 2-formyl-4-chloro-3-fluoropyridine 10 regioselectively, which was converted to 2-aminomethyl analogue 1 via sulfinamide 2. Alternatively, Minisci-type amidomethylation under Ag+/persulfate or photoredox-mediated conditions using a series of amino acid derivatives gave (3-8, 19, and 34) in 30-74% yield and isomer ratios in the range 6.7:1 to >50:1. The latter methods gave overall yields similar to that of the deprotonation approach, but were shorter and more amenable to scale-up. In particular, N-Boc analogue 8 was obtained in a single step. The amidomethylations of another six 3-fluoropyridines under the photoredox conditions were briefly examined.