Technology Process of 3-[(4R,6S)-1,8-Dichloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoic acid
There total 13 articles about 3-[(4R,6S)-1,8-Dichloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Methyl 3-[(4R,6S)-1,8-dichloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoate;
With
methanol; water; potassium carbonate;
In
tetrahydrofuran;
at 20 ℃;
With
Amberlite IR-120B;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: trichlorophosphate / 0.17 h / 0 - 20 °C
1.2: 2 h / 50 °C / Heating / reflux
1.3: 0.5 h / Heating / reflux
2.1: toluene / 100 °C
3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 20 °C
5.1: Resolution of racemate
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C
6.2: 3 h / 0 °C
7.1: triethylamine / dichloromethane / 3 h / 0 °C
8.1: dimethyl sulfoxide / 13 h / 50 °C
9.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux
9.2: 0 °C
10.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
11.1: N-chloro-succinimide / tetrahydrofuran / 20 °C
12.1: methanol; water; potassium carbonate / tetrahydrofuran / 20 °C
12.2: Amberlite IR-120B
With
methanol; sodium hydroxide; sodium tetrahydroborate; N-chloro-succinimide; lithium aluminium tetrahydride; water; potassium carbonate; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux
1.2: 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: N-chloro-succinimide / tetrahydrofuran / 20 °C
4.1: methanol; water; potassium carbonate / tetrahydrofuran / 20 °C
4.2: Amberlite IR-120B
With
methanol; sodium hydroxide; N-chloro-succinimide; water; potassium carbonate; isopropyl alcohol;
In
tetrahydrofuran; N,N-dimethyl-formamide;
![Methyl 3-[(4R,6S)-1,8-dichloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoate](/Databaselist/images/loading.webp)
