ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• CAS No.: 423737-44-4
• Molecular Formula: C₁₅H₁₈N₂O₃S
• Molecular Weight: 306.386
• Mol file: 423737-44-4.mol

Synonyms:ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property of ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 1 articles about ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetoacetate (141-97-9) + urea (57-13-6) + 4-(Methylthio)benzaldehyde (3446-89-7) → ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (423737-44-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In ethanol; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.150

Reference yield: 91.0%

ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (423737-44-4) → C15H16N2O3S (1451203-41-0)

Guidance literature:

With 1,4-bis(triphenylphosphonium)-2-butene peroxodisulfate; water; In acetonitrile; at 80 ℃; chemoselective reaction;

DOI:10.5012/bkcs.2013.34.6.1751

Reference yield: 85.0%

ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (423737-44-4) → C15H18N2O4S (1017241-27-8)

Guidance literature:

With urea hydrogen peroxide adduct; phosphomolybdic acid hydrate; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2008.01.009

upstream raw materials:

ethyl acetoacetate

urea

4-(Methylthio)benzaldehyde

Downstream raw materials:

C₁₅H₁₈N₂O₄S

C₁₅H₁₈N₂O₅S

C₁₅H₁₆N₂O₃S

Refernces

• 1、 Zafar, Humaira,Iqbal, Sarosh,Javaid, Sumaira,Khan, Khalid M.,Choudhary, Muhammad I.. "Xanthine oxidase inhibitory and molecular docking studies on pyrimidones". . p. 524 - 535. Retrieved 2018/07/25.
• 2、 Da Silva, Daniel L.,Fernandes, Sergio A.,Sabino, Ad?o A.,De Fá, ?ngelo. "P-Sulfonic acid calixarenes as efficient and reusable organocatalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones". experimental part. p. 6328 - 6330. Retrieved 2011/12/22.