tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

Base Information

Chemical Name:tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate
CAS No.:1616435-34-7
Molecular Formula:C₁₉H₂₉Cl₂N₃O₂
Molecular Weight:402.364
Hs Code.:

Synonyms:tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

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Chemical Property of tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

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Technology Process of tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

There total 9 articles about tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1616435-33-6
tert-butyl (2,6-dichloro-3-((-1-((trans)-4-methylcyclohexyl)ethylidene)amino)pyridin-4-yl)carbamate

: 1616435-34-7
tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In ethanol; at 50 ℃; for 4h;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616435-34-7
tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

4.1: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 910910-20-2
(1r,4r)-N-methoxy-N,4-dimethylcyclohexane-1-carboxamide

: 1616435-34-7
tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C

2: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

3: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; ethanol; toluene;