6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine
CAS No.:1616435-37-0
Molecular Formula:C₂₀H₂₂Cl₂N₄
Molecular Weight:389.327
Hs Code.:

Synonyms:6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

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Chemical Property of 6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

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Technology Process of 6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

There total 8 articles about 6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 872041-85-5
(5-chloro-3-pyridyl)boronic acid

: 1616435-36-9
4,6-dichloro-3-(1-((trans)-4-methylcyclohexyl)ethyl)-3H-imidazo[4,5-c]pyridine

: 1616435-37-0
6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 1313726-52-1
tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate

: 1616435-37-0
6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: iron; water / ethanol / 10 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

3: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

4: hydrogenchloride / 1,4-dioxane / 12 h / 50 °C

5: 3 h / 100 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; iron; sodium cyanoborohydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1616435-37-0
6-chloro-4-(5-chloropyridin-3-yl)-3-[1-(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -20 - 20 °C

2: iron; water / ethanol / 10 h / 20 °C

3: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

4: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

5: hydrogenchloride / 1,4-dioxane / 12 h / 50 °C

6: 3 h / 100 °C

7: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; iron; sodium cyanoborohydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;