dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate

Base Information

• Chemical Name: dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate
• CAS No.: 104156-50-5
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.358
• Mol file: 104156-50-5.mol

Synonyms:dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate

Chemical Property of dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate

There total 3 articles about dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodure de N,N,N-trimethyl hydrazonium de l'isobutyrophenon (56062-73-8) → dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate (104156-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) 2-propanol, 35 deg C, 2 h

2: 55 percent / benzene / 36 h / 25 °C / Irradiation

3: 2.) NaBH₄ / 1.) 70 deg C, 1 h, 2.) EtOH, 25 deg C, 2 h

With sodium tetrahydroborate; sodium hydride; In benzene;

DOI:10.1021/jm00161a019

Reference yield:

2,2-dimethyl-3-phenyl-2H-azirine (14491-02-2) → dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate (104156-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / benzene / 36 h / 25 °C / Irradiation

2: 2.) NaBH₄ / 1.) 70 deg C, 1 h, 2.) EtOH, 25 deg C, 2 h

With sodium tetrahydroborate; In benzene;

DOI:10.1021/jm00161a019

Reference yield:

2,2-Dimethyl-5-phenyl-2H-pyrrol-3,4-dicarbonsaure-dimethylester (61728-55-0) + dimethyl sulfate (77-78-1) → dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate (104156-50-5)

Guidance literature:

With sodium tetrahydroborate; Yield given. Multistep reaction; 1.) 70 deg C, 1 h, 2.) EtOH, 25 deg C, 2 h;

DOI:10.1021/jm00161a019

upstream raw materials:

2,2-Dimethyl-5-phenyl-2H-pyrrol-3,4-dicarbonsaure-dimethylester

dimethyl sulfate

iodure de N,N,N-trimethyl hydrazonium de l'isobutyrophenon

2,2-dimethyl-3-phenyl-2H-azirine

Downstream raw materials:

1,2,2-trimethyl-5-phenyl-3,4-bis(hydroxymethyl)-3-pyrroline

1,2,2-trimethyl-5-phenyl-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline