<1S-<1R,2S,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Base Information

Chemical Name:<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide
CAS No.:142103-36-4
Molecular Formula:C₃₄H₅₄N₆O₇S₂
Molecular Weight:722.971
Hs Code.:

<1S-<1R*<R*(R*)>,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Synonyms:<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

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Chemical Property of <1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

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Technology Process of <1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

There total 7 articles about <1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 142103-52-4
(4-{(S)-3-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-3-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-propyl}-thiazol-2-yl)-carbamic acid benzyl ester

: 142103-36-4
<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Guidance literature:: With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; for 24h;
DOI:10.1021/jm00092a006

Reference yield:

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 142103-36-4
<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

3: 2.97 g / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

4: 35 percent / H₂, p-toluenesulfonic acid hydrate / 20percent Pd/C / methanol / 24 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 132286-82-9
(S)-4-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

: 142103-36-4
<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: aq. NaOH / ethanol / 4 h / Ambient temperature

3: 58 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

4: HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

5: 2.97 g / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

6: 35 percent / H₂, p-toluenesulfonic acid hydrate / 20percent Pd/C / methanol / 24 h

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006