(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid

Base Information

• Chemical Name: (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid
• CAS No.: 142103-50-2
• Molecular Formula: C₂₀H₂₅N₃O₆S
• Molecular Weight: 435.501

Synonyms:(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid

Chemical Property of (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid

Chemical Property:

Purity/Quality:

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Technology Process of (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid

There total 3 articles about (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester (142103-49-9) → (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid (142103-50-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Yield given; Ambient temperature;

DOI:10.1021/jm00092a006

Reference yield:

(S)-4-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester (132286-82-9) → (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid (142103-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: aq. NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00092a006

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid (142103-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: aq. NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00092a006

upstream raw materials:

(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

(S)-4-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

benzyl chloroformate

Downstream raw materials:

(4-{(S)-3-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-3-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-propyl}-thiazol-2-yl)-carbamic acid benzyl ester

<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

{4-[(S)-3-tert-Butoxycarbonylamino-3-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid benzyl ester

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