1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

Base Information

Chemical Name:1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine
CAS No.:1403387-97-2
Molecular Formula:C₂₄H₃₆N₂O₂S
Molecular Weight:416.628
Hs Code.:

Synonyms:1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

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Chemical Property of 1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

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Technology Process of 1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

There total 5 articles about 1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1403387-96-1
5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylic acid

: 1403387-97-2
1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

Guidance literature:: 5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylic acid; With trifluoroacetic acid; at 100 ℃; for 0.5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 35856-62-3
1-piperidinesulfonyl chloride

: 1403387-97-2
1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 0 - 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C

4.1: sodium hydroxide; water / methanol / 3 h / Reflux

4.2: pH 2

5.1: trifluoroacetic acid / 0.5 h / 100 °C

With N-Bromosuccinimide; water; sodium hydride; sodium carbonate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki Coupling;

Reference yield:

: 1403387-93-8
ethyl 2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylate

: 1403387-97-2
1-((2-(3,5-di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 0 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C

3.1: sodium hydroxide; water / methanol / 3 h / Reflux

3.2: pH 2

4.1: trifluoroacetic acid / 0.5 h / 100 °C

With N-Bromosuccinimide; water; sodium carbonate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;