4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Base Information

Chemical Name:4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid
CAS No.:1562995-45-2
Molecular Formula:C₂₅H₁₉ClFN₃O₃
Molecular Weight:463.896
Hs Code.:

Synonyms:4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

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Chemical Property of 4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

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Technology Process of 4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

There total 10 articles about 4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1562995-56-5
2-chloro-6-cyclopentylbenzoyl chloride

: 1562995-93-0
3-fluoro-4-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzoic acid

: 1562995-45-2
4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: 3-fluoro-4-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzoic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -30 - 15 ℃; for 2h;

2-chloro-6-cyclopentylbenzoyl chloride; In tetrahydrofuran; at 0 - 15 ℃; for 4.5h;

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1562995-45-2
4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 14 h / Reflux

4.1: water; sodium hydroxide / methanol / 1 h / 60 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 - 15 °C

5.2: 4.5 h / 0 - 15 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; toluene-4-sulfonic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; toluene; 2.1: |Suzuki Coupling;

Reference yield:

: 1562995-68-9
3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridine

: 1562995-45-2
4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 14 h / Reflux

3.1: water; sodium hydroxide / methanol / 1 h / 60 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 - 15 °C

4.2: 4.5 h / 0 - 15 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; toluene; 1.1: |Suzuki Coupling;