bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

Base Information

Chemical Name:bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine
CAS No.:1241096-35-4
Molecular Formula:C₅₁H₅₄N₆O₅
Molecular Weight:831.027
Hs Code.:

Synonyms:bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

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Chemical Property of bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

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Technology Process of bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

There total 7 articles about bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241096-34-3
allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

: 1241096-35-4
bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

Guidance literature:: With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 4h; Vacuum;

Reference yield:

: L-3-(naphthalen-2-yl)alanine hydrochloride

: 1241096-35-4
bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 0 °C

1.2: 0 °C / pH 2 / Acidic conditions

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

3.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: dichloromethane / 2 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.3: 0.5 h / 20 °C

7.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 20 °C / under vacuum

With 1,3-dimethylbarbituric acid; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1185841-47-7
(S)-2-(allyloxycarbonylamino)-3-(naphthalen-2-yl)propanoic acid

: 1241096-35-4
bis(Cbz) 1-(3-((2S,7RS)-7-((S)-1-amino-2-(naphthalen-2-yl)ethyl)-4-(2,2-diphenylethyl)-3-oxo-1,4-diazepan-2-yl)propyl)guanidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: dichloromethane / 2 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.3: 0.5 h / 20 °C

6.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 20 °C / under vacuum

With 1,3-dimethylbarbituric acid; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;