allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

Base Information

Chemical Name:allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate
CAS No.:1241096-34-3
Molecular Formula:C₅₅H₅₈N₆O₇
Molecular Weight:915.102
Hs Code.:

Synonyms:allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

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Chemical Property of allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

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Technology Process of allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

There total 3 articles about allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241096-33-2
(S)-allyl 5-(N-(Boc-L-Arg(Cbz)2)-2,2-diphenylethylamino)-1-(naphthalen-2-yl)-3-oxopentan-2-ylcarbamate

: 1241096-34-3
allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

Guidance literature:: (S)-allyl 5-(N-(Boc-L-Arg(Cbz)2)-2,2-diphenylethylamino)-1-(naphthalen-2-yl)-3-oxopentan-2-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: L-3-(naphthalen-2-yl)alanine hydrochloride

: 1241096-34-3
allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 0 °C

1.2: 0 °C / pH 2 / Acidic conditions

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

3.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: dichloromethane / 2 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.3: 0.5 h / 20 °C

With sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1185841-47-7
(S)-2-(allyloxycarbonylamino)-3-(naphthalen-2-yl)propanoic acid

: 1241096-34-3
allyl (S)-1-((3S,5RS)-1-(2,2-diphenylethyl)-3-(bis(Cbz)-3-guanidinopropyl)-2-oxo-1,4-diazepan-5-yl)-2-(naphthalen-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: dichloromethane / 2 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.3: 0.5 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;