1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

Base Information

Chemical Name:1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole
CAS No.:116911-66-1
Molecular Formula:C₂₆H₂₄N₄O₉S₂
Molecular Weight:600.63
Hs Code.:

1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-<N-(2-propenyl)methanesulfonamido>indole

Synonyms:1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

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Chemical Property of 1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

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Technology Process of 1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

There total 9 articles about 1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 116911-63-8
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-5-indole

: 116911-65-0
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4-nitro-5-indole

: 116911-66-1
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

Guidance literature:: With ammonium nitrate; trifluoroacetic anhydride; In chloroform; for 6h; Yields of byproduct given;
DOI:10.1021/jo00256a036

Reference yield:

: 25351-89-7
N-(2-hydroxy-4-nitrophenyl)acetamide

: 116911-66-1
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / KI, K₂CO₃ / dimethylformamide / 4 h

2: Zn, CaCl₂, ethanol / 1.5 h / Heating

3: 80 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

4: 80 percent / potessium tert-butoxide / dimethylformamide / 3 h / Ambient temperature

5: 82 percent / 50percent aq. KOH / ethanol / 8 h / Heating

6: 1.) NaNO₂, HCl, SnCl₂ / 1.) 2 h, 2.) RT, 12 h

7: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.)THF, RT, 8 h

8: 57 percent / ammonium nitrate, trifluoroacetic anhydride / CHCl₃ / 6 h

With pyridine; hydrogenchloride; potassium hydroxide; ammonium nitrate; ethanol; potassium tert-butylate; sodium hydride; potassium carbonate; trifluoroacetic anhydride; potassium iodide; calcium chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo00256a036

Reference yield:

: 25945-95-3
N-<2-(benzyloxy)-4-nitrophenyl>acetamide

: 116911-66-1
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4,6-dinitro-5-indole

Guidance literature:: Multi-step reaction with 7 steps

1: Zn, CaCl₂, ethanol / 1.5 h / Heating

2: 80 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

3: 80 percent / potessium tert-butoxide / dimethylformamide / 3 h / Ambient temperature

4: 82 percent / 50percent aq. KOH / ethanol / 8 h / Heating

5: 1.) NaNO₂, HCl, SnCl₂ / 1.) 2 h, 2.) RT, 12 h

6: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.)THF, RT, 8 h

7: 57 percent / ammonium nitrate, trifluoroacetic anhydride / CHCl₃ / 6 h

With pyridine; hydrogenchloride; potassium hydroxide; ammonium nitrate; ethanol; potassium tert-butylate; sodium hydride; trifluoroacetic anhydride; calcium chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo00256a036