25945-95-3Relevant academic research and scientific papers
Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: Synthesis, biological evaluation, and ligand-based pharmacophore identification
Su, Bin,Tian, Ran,Darby, Michael V.,Brueggemeier, Robert W.
, p. 1126 - 1135 (2008/09/20)
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. Previously, the COX-2 selective inhibitor nimesulide and analogs decreased aromatase expression and enzyme acti
SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS
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, (2010/11/28)
Compounds and methods suppressing aromatase activity expression in cancer cells. Provided are compounds are those of formula I: wherein R1 may be alkyl, cycloakyl, haloalkyl, aryl, substituted aryl, haloaryl, alkoxy, alkylaryl, and arylalkyl; R2 is H, alk
PHOTOCHEMISTRY OF QUINONE DIAZIDES. INTRAMOLECULAR OXYGEN TRANSFER AND CARBENOID ADDITION DURING PHOTOLYSIS OF N-ALLYLSULFONAMIDO QUINONE DIAZIDES
Sundberg, Richard J.,Baxter, Ellen W.
, p. 2687 - 2690 (2007/10/02)
An indole quinone diazide, 5-(N-allylsulfonamido)-4-diazo-3-methyl-4,7-dihydroindol-7-one, which is a potential precursor of a spiro-cyclopropane-indol-7-one structure has been prepared.A study of its photolysis and that of a model compound has identified oxygen transfer from the sulfonamido substituent as a process which competes with intramolecular carbenoid addition.
