4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

Base Information

Chemical Name:4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one
CAS No.:269405-65-4
Molecular Formula:C₂₃H₂₀N₂O₂
Molecular Weight:356.424
Hs Code.:

Synonyms:4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

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Chemical Property of 4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

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Technology Process of 4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

There total 3 articles about 4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 594-27-4
tetramethylstannane

: 269405-64-3
trifluoromethanesulfonic acid 4-benzoyl-7-methyl-8-oxo-4,5,5a,6,7,8-hexahydroindolo[4,3-fg]quinolin-9-yl ester

: 269405-65-4
4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;
DOI:10.1021/jo9915729

Reference yield:

: 1025809-63-5
4-benzoyl-9-hydroxy-7-methyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

: 269405-65-4
4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: 0.4 g / Et₃N / CH₂Cl₂ / 12 h

2: 73 percent / LiCl; Pd(PPh₃)2Cl₂ / dimethylformamide / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Methylation;
DOI:10.1021/jo9915729

Reference yield:

: 269405-61-0
acetic acid 4-benzoyl-7-methyl-8-oxo-4,5,5a,6,7,8-hexahydroindolo[4,3-fg]quinolin-9-yl ester

: 269405-65-4
4-benzoyl-7,8-dimethyl-4,5,5a,7-tetrahydro-6H-indolo[4,3-fg]quinolin-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / methanol / 3 h / 20 °C

2: 0.4 g / Et₃N / CH₂Cl₂ / 12 h

3: 73 percent / LiCl; Pd(PPh₃)2Cl₂ / dimethylformamide / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; lithium chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Deacetylation / 2: Substitution / 3: Methylation;
DOI:10.1021/jo9915729