{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

Base Information

Chemical Name:{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane
CAS No.:331628-41-2
Molecular Formula:C₃₈H₆₂O₅SSi
Molecular Weight:659.059
Hs Code.:

{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

Synonyms:{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

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Chemical Property of {(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

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Technology Process of {(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

There total 9 articles about {(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 53750-52-0
4-iodo-2-methyl-but-1-ene

: 331627-52-2
(1S,2R,5R,8aR)-1,2,3,5,6,7,8,8a-octahydro-5-benzenesulfonylmethyl-1-tert-butyldimethylsilyloxymethyl-2,5-dimethyl-1-[2-(tetrahydro-2-pyranyloxy)ethyl]naphthalene

: 331628-41-2
{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 50 ℃; for 2h;
DOI:10.1021/jo0015772

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 331628-41-2
{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 16.6 g / imidazole / dimethylformamide / 10 h / 20 °C

2: 93 percent / MeLi; TMEDA / tetrahydrofuran / 0 - 20 °C

3: Li; MeNH₂ / 2-methyl-propan-2-ol; tetrahydrofuran / Heating

4: n-Bu₃P; pyridine / 6 h / 20 °C

5: aq. H₂O₂ / pyridine; diethyl ether

6: 2.14 g / TPAP; molecular sieves; NMO / CH₂Cl₂ / 2 h / 20 °C

7: 93 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 50 °C

With pyridine; 1H-imidazole; n-butyllithium; N-methyl-2-indolinone; molecular sieve; tetrapropylammonium perruthennate; N,N,N,N,-tetramethylethylenediamine; tributylphosphine; methyllithium; dihydrogen peroxide; lithium; methylamine; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Benkeser reduction;
DOI:10.1021/jo0015772

Reference yield:

: 331627-46-4
(1R,4R,7R,8S,8aR)-1,2,3,4,6,7,8,8a-octahydro-4-benzyloxymethyl-4,7-dimethyl-8-tert-butyldimethylsilyloxymethyl-8-[2-(tetrahydro-2-pyranyloxy)ethyl]-1-naphthalenol

: 331628-41-2
{(1S,2R,5R,8aR)-5-(1-Benzenesulfonyl-4-methyl-pent-4-enyl)-2,5-dimethyl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-ylmethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / MeLi; TMEDA / tetrahydrofuran / 0 - 20 °C

2: Li; MeNH₂ / 2-methyl-propan-2-ol; tetrahydrofuran / Heating

3: n-Bu₃P; pyridine / 6 h / 20 °C

4: aq. H₂O₂ / pyridine; diethyl ether

5: 2.14 g / TPAP; molecular sieves; NMO / CH₂Cl₂ / 2 h / 20 °C

6: 93 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 50 °C

With pyridine; n-butyllithium; N-methyl-2-indolinone; molecular sieve; tetrapropylammonium perruthennate; N,N,N,N,-tetramethylethylenediamine; tributylphosphine; methyllithium; dihydrogen peroxide; lithium; methylamine; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane; tert-butyl alcohol; 2: Benkeser reduction;
DOI:10.1021/jo0015772