Diethyl 5-(4-nitrophenylmethyloxy)isophthalate

Base Information

• Chemical Name: Diethyl 5-(4-nitrophenylmethyloxy)isophthalate
• CAS No.: 350671-21-5
• Molecular Formula: C₁₉H₁₉NO₇
• Molecular Weight: 373.362
• Mol file: 350671-21-5.mol

Synonyms:Diethyl 5-(4-nitrophenylmethyloxy)isophthalate

Chemical Property of Diethyl 5-(4-nitrophenylmethyloxy)isophthalate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl 5-(4-nitrophenylmethyloxy)isophthalate

There total 2 articles about Diethyl 5-(4-nitrophenylmethyloxy)isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

diethyl 5-hydroxyisophthalate (39630-68-7) + 1-bromomethyl-4-nitro-benzene (100-11-8) → Diethyl 5-(4-nitrophenylmethyloxy)isophthalate (350671-21-5)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1055/s-2001-13392

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → Diethyl 5-(4-nitrophenylmethyloxy)isophthalate (350671-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / AcCl / 4 h / Heating

2: 96.5 percent / K₂CO₃ / acetone / 2 h / Heating

With potassium carbonate; acetyl chloride; In acetone;

DOI:10.1055/s-2001-13392

Reference yield: 90.9%

2.6-diaminopyridine (141-86-6) + Diethyl 5-(4-nitrophenylmethyloxy)isophthalate (350671-21-5) → N,N'-Bis[2-(6-aminopyridyl)]-5-(4-nitrophenylmethyloxy)isophthaldiamide (350671-22-6)

Guidance literature:

2.6-diaminopyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

Diethyl 5-(4-nitrophenylmethyloxy)isophthalate; In tetrahydrofuran; hexane; at -78 - -60 ℃; for 6h;

DOI:10.1055/s-2001-13392

upstream raw materials:

diethyl 5-hydroxyisophthalate

1-bromomethyl-4-nitro-benzene

5-Hydroxyisophthalic acid

Downstream raw materials:

N,N'-Bis[2-(6-aminopyridyl)]-5-(4-nitrophenylmethyloxy)isophthaldiamide

N,N'-Bis[2-(6-butyrylaminopyridyl)]-5-(4-nitrophenylmethyloxy)isophthaldiamide

Refernces