Technology Process of methyl (2S,3R)-2-[(tert-butoxycarbonyl)amino]-3-phenylbutanoate
There total 14 articles about methyl (2S,3R)-2-[(tert-butoxycarbonyl)amino]-3-phenylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 12h;
under 760 Torr;
DOI:10.1021/jo971178f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium bicarbonate; sodium periodate / ruthenium trichloride trihydrate / CCl4; acetonitrile; H2O / 48 h
2.1: CuCN / diethyl ether; hexane / 0 °C
2.2: diethyl ether; hexane / 4 h / 0 °C
3.1: 0.18 g / KHCO3 / dimethylformamide / 12 h / 20 °C
4.1: 82 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / 0 - 20 °C
5.1: sodium azide / dimethylformamide / 12 h / 80 °C
6.1: 0.32 g / H2 / Pd/C / ethyl acetate / 12 h / 760 Torr
With
dmap; sodium periodate; sodium azide; hydrogen; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine;
ruthenium trichloride; palladium on activated charcoal;
In
tetrachloromethane; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
1.1: Oxidation / 2.1: transmetallation / 2.2: Ring cleavage / 3.1: Esterification / 4.1: mesylation / 5.1: Substitution / 6.1: Catalytic hydrogenation;
DOI:10.1021/jo971178f
- Guidance literature:
-
Multi-step reaction with 7 steps
2: KOH / ethanol
3: diethyl ether
4: 0.18 g / KHCO3 / dimethylformamide / 12 h / 20 °C
5: 82 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / 0 - 20 °C
6: sodium azide / dimethylformamide / 12 h / 80 °C
7: 0.32 g / H2 / Pd/C / ethyl acetate / 12 h / 760 Torr
With
dmap; potassium hydroxide; sodium azide; hydrogen; potassium hydrogencarbonate; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1: Jacobsen's epoxidation / 2: Hydrolysis / 3: Ring cleavage / 4: Esterification / 5: mesylation / 6: Substitution / 7: Catalytic hydrogenation;
DOI:10.1021/jo971178f
