(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

Base Information

Chemical Name:(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one
CAS No.:1357918-03-6
Molecular Formula:C₁₉H₁₉NO₄S
Molecular Weight:357.43
Hs Code.:

Synonyms:(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

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Chemical Property of (1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

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Technology Process of (1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

There total 6 articles about (1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₇NO₄S

: 1357918-03-6
(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1039/c2cc17149j

Reference yield:

: 154780-68-4
2-benzylideneamino-N-methyl-N-methoxyacetamide

: 1357918-03-6
(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine / tetrahydrofuran / 40 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

3: lithium hexamethyldisilazane / tetrahydrofuran / 14 h / Inert atmosphere

4: sodium tetrahydroborate / ethanol / 15 h / 20 °C / Inert atmosphere

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; sodium tetrahydroborate; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1039/c2cc17149j

Reference yield:

: 1357918-02-5
(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

: 1357918-03-6
(1S,5R,6S,7aR)-1-hydroxy-5-phenyl-6-(phenylsulfonyl)tetrahydro-1H-pyrrolizin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 14 h / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 15 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1039/c2cc17149j