(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

Base Information

Chemical Name:(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide
CAS No.:1357918-02-5
Molecular Formula:C₂₁H₂₄N₂O₅S
Molecular Weight:416.498
Hs Code.:

Synonyms:(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

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Chemical Property of (2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

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Technology Process of (2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

There total 4 articles about (2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1357917-95-3
(2R,4S,5R)-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

: 75-36-5
acetyl chloride

: 1357918-02-5
(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 10h; Inert atmosphere;
DOI:10.1039/c2cc17149j

Reference yield:

: 154780-68-4
2-benzylideneamino-N-methyl-N-methoxyacetamide

: 1357918-02-5
(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine / tetrahydrofuran / 40 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; In tetrahydrofuran;
DOI:10.1039/c2cc17149j

Reference yield:

: 5535-48-8
PVS

: 1357918-02-5
(2R,4S,5R)-1-acetyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine / tetrahydrofuran / 40 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; In tetrahydrofuran;
DOI:10.1039/c2cc17149j