2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Base Information

Chemical Name:2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide
CAS No.:147283-34-9
Molecular Formula:C₂₅H₃₆F₃N₃O₃Si
Molecular Weight:511.66
Hs Code.:

Synonyms:2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

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Chemical Property of 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

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Technology Process of 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

There total 18 articles about 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 147269-02-1
2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

: 147283-34-9
2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Guidance literature:: With sodium methylate; In methanol; ethanol; for 18h;
DOI:10.1021/jm00046a015

Reference yield: 92.2%

: 147313-49-3
2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: 147283-34-9
2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Guidance literature:: With sodium methylate; palladium; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 147283-34-9
2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h

2: sodium iodide / acetone / 12 h / Ambient temperature

3: sodium hydride / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

4: sodium methylate / methanol; ethanol / 18 h

With 2,6-dimethylpyridine; sodium methylate; sodium hydride; sodium iodide; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jm00046a015