2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine

Base Information

• Chemical Name: 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine
• CAS No.: 1202075-93-1
• Molecular Formula: C₂₃H₁₇FN₂S
• Molecular Weight: 372.466

Synonyms:2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine

Chemical Property of 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine

Chemical Property:

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Technology Process of 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine

There total 2 articles about 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H27FN2OSSi → 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (1202075-93-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2011.12.073

Reference yield:

3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (1202075-59-9) → 2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (1202075-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

With potassium tert-butylate; In tetrahydrofuran; 1: Peterson olefination / 2: Peterson olefination;

DOI:10.1016/j.bmcl.2011.12.073

Reference yield: 90.0%

2-(2-fluoro-4-vinylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (1202075-93-1) + diethyl malonate (105-53-3) → C30H29FN2O4S (1202077-60-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 35 ℃; for 2.5h;

DOI:10.1016/j.bmcl.2011.12.073

upstream raw materials:

3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde

Downstream raw materials:

C₂₅H₂₂FN₃O₂S

C₃₀H₃₀FN₃O₄S

C₃₀H₃₀FN₃O₄S

C₃₀H₃₀FN₃O₄S

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