(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Base Information

Chemical Name:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine
CAS No.:156365-92-3
Molecular Formula:C₂₁H₃₃NO₄
Molecular Weight:363.497
Hs Code.:

Synonyms:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Technology Process of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

There total 6 articles about (2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 917-64-6
methyl magnesium iodide

: 156365-87-6
(2S,4S,5R)-4-methyl-2-(1-oxo)pentyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

: 156365-92-3
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: In diethyl ether; at 0 ℃;
DOI:10.1016/S0040-4039(00)76893-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 156365-92-3
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) toluene, reflux; 2.) AcOEt, 50 deg C, rapid addition

2: 90 percent / LiOH

3: 70 percent / DCC / pyridine

4: 55 percent / tetrahydrofuran

5: 91 percent / diethyl ether / 0 °C

With lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; diethyl ether;
DOI:10.1016/S0040-4039(00)76893-6

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 156365-92-3
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-methyl)pentyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) toluene, reflux; 2.) AcOEt, 50 deg C, rapid addition

2: 90 percent / LiOH

3: 70 percent / DCC / pyridine

4: 55 percent / tetrahydrofuran

5: 91 percent / diethyl ether / 0 °C

With lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; diethyl ether;
DOI:10.1016/S0040-4039(00)76893-6