C₂₁H₁₆F₄N₂O₂

Base Information

Chemical Name:C₂₁H₁₆F₄N₂O₂
CAS No.:1590403-10-3
Molecular Formula:C₂₁H₁₆F₄N₂O₂
Molecular Weight:404.364
Hs Code.:

C<sub>21</sub>H<sub>16</sub>F<sub>4</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₂₁H₁₆F₄N₂O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₆F₄N₂O₂

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Technology Process of C₂₁H₁₆F₄N₂O₂

There total 7 articles about C₂₁H₁₆F₄N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1590403-04-5
C₂₁H₁₂F₄N₂O₂

: 1590403-10-3
C₂₁H₁₆F₄N₂O₂

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; water; for 18h; under 2327.23 Torr;

Reference yield:

: 58539-65-4
2-methylnicotinamide

: 1590403-10-3
C₂₁H₁₆F₄N₂O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 50 °C

1.2: 2.5 h / 80 °C

2.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3.5 h / 20 °C

3.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 18 h / 20 °C / Molecular sieve

4.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 18 h / 100 °C / Inert atmosphere

5.1: hydrogen; palladium on activated charcoal / water; methanol / 18 h / 2327.23 Torr

With pyridine; pyridine N-oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; oxygen; copper diacetate; potassium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 23616-31-1
1,6-naphthyridine-5(6H)-one

: 1590403-10-3
C₂₁H₁₆F₄N₂O₂

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3.5 h / 20 °C

2: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 18 h / 20 °C / Molecular sieve

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 18 h / 100 °C / Inert atmosphere

4: hydrogen; palladium on activated charcoal / water; methanol / 18 h / 2327.23 Torr

With pyridine; pyridine N-oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; oxygen; copper diacetate; potassium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane;