ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate

Base Information

• Chemical Name: ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate
• CAS No.: 153864-76-7
• Molecular Formula: C₁₆H₁₇ClO₄
• Molecular Weight: 308.762
• Mol file: 153864-76-7.mol

Synonyms:ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate

Chemical Property of ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate

There total 13 articles about ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chlorophenylglyoxal (4998-15-6) + (E)-3-Ethoxy-4-(triphenyl-λ5-arsanylidene)-but-2-enoic acid ethyl ester (178754-83-1) → ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate (153864-76-7)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 9.5h;

DOI:10.1248/cpb.44.885

Reference yield: 91.0%

4-chlorophenylglyoxal (4998-15-6) + (E)-3-Ethoxy-4-(triphenyl-λ5-arsanylidene)-but-2-enoic acid ethyl ester (178754-83-1) → ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate (153864-76-7) + (E)-3-[(1R,3R)-2-(4-Chloro-benzoyl)-3-((E)-1-ethoxy-2-ethoxycarbonyl-vinyl)-cyclopropyl]-3-ethoxy-acrylic acid ethyl ester

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; dichloromethane; for 9h; Ambient temperature;

DOI:10.1248/cpb.44.885

Reference yield: 84.0%

(E)-[2-ethoxy-3-(ethoxycarbonyl)-2-propenylidene]triphenylphosphorane (145822-68-0) + 4-chlorophenylglyoxal (4998-15-6) → ethyl (2E,4E)-6-(4-chlorophenyl)-3-ethoxy-6-oxo-2,4-hexadienoate (153864-76-7)

Guidance literature:

In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1248/cpb.44.885

upstream raw materials:

(E)-[2-ethoxy-3-(ethoxycarbonyl)-2-propenylidene]triphenylphosphorane

4-chlorobenzoylmethyl bromide

4-chlorophenylglyoxal

(E)-3-Ethoxy-4-(triphenyl-λ⁵-arsanylidene)-but-2-enoic acid ethyl ester