4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol

Base Information

• Chemical Name: 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol
• CAS No.: 851550-31-7
• Molecular Formula: C₂₀H₂₄BrClN₂O₂
• Molecular Weight: 439.78
• Mol file: 851550-31-7.mol

Synonyms:4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol

Chemical Property of 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol

There total 8 articles about 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-1-oxa-6-azaspiro[2.5]octane (851550-30-6) → 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol (851550-31-7)

Guidance literature:

With ammonium hydroxide; In methanol; at 60 ℃;

DOI:10.1016/j.bmcl.2007.01.050

Reference yield:

6-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-1-oxa-6-azaspiro[2.5]octane (851550-30-6) → 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol (851550-31-7) + 1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-[[[[1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-hydroxy-4-piperidinyl]methyl]amino]methyl]-4-piperidinol

Guidance literature:

With ammonia; In methanol; water; at 75 ℃;

Reference yield:

[5-bromo-2-(4-chloro-benzyloxy)-phenyl]-methanol (690965-23-2) → 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol (851550-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: CBr₄; PPh₃ / CH₂Cl₂

2: K₂CO₃ / dimethylformamide / 20 °C

3: 94 percent / potassium tert-butoxide / dimethylsulfoxide / 6 h / 20 °C

4: 81 percent / aq. NH₃ / methanol / 60 °C

With ammonium hydroxide; carbon tetrabromide; potassium tert-butylate; potassium carbonate; triphenylphosphine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.01.050

upstream raw materials:

6-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-1-oxa-6-azaspiro[2.5]octane

[5-bromo-2-(4-chloro-benzyloxy)-phenyl]-methanol

4-bromo-2-(bromomethyl)-1-[(4-chlorophenyl)methoxy]benzene

1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinone