690965-23-2

Upstream product

• 428482-55-7 5-bromo-2-((4-chlorobenzyl)oxy)benzaldehyde 
• 1761-61-1 5-bromosalicyclaldehyde 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 851550-31-7 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol 
• 851550-30-6 6-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-1-oxa-6-azaspiro[2.5]octane 
• 851547-40-5 1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinone 
• 851546-88-8 5-bromo-2-[(4-chlorophenyl)methoxy]-N,N-dimethylbenzenemethanamine 
• 851547-27-8 4-bromo-2-(bromomethyl)-1-[(4-chlorophenyl)methoxy]benzene 

Relevant academic research and scientific papers

CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives

The guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde, 1, with an IC50 of 840 nM against the CCR5 receptor was identified using high-throughput screening. Optimization efforts led to the discovery of a novel piperidine series of CCR5

BENZYLETHER AMINE COMPOUNDS USEFUL AS CCR-5 ANTAGONISTS

The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising suc