Technology Process of N-(4-methoxyphenyl)-2-(1-phenyl-1H-1,2,3-triazol-4-yl)aniline
There total 3 articles about N-(4-methoxyphenyl)-2-(1-phenyl-1H-1,2,3-triazol-4-yl)aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2-bromophenyl)-1-phenyl-1-H-1,2,3-triazole;
With
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate;
In
toluene;
for 0.0833333h;
4-methoxy-aniline;
In
toluene;
at 100 ℃;
for 48h;
DOI:10.1021/ic102338g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / water; tert-butyl alcohol / 0.17 h
1.2: 0.25 h / Inert atmosphere
1.3: 25 h / 20 - 60 °C / Inert atmosphere
2.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate / toluene / 0.08 h
2.2: 48 h / 100 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; sodium t-butanolate;
In
water; toluene; tert-butyl alcohol;
1.3: Huisgen cycloaddition;
DOI:10.1021/ic102338g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / 0.5 h / Inert atmosphere
1.2: 5 h / 25 °C / Inert atmosphere
2.1: potassium carbonate / water; tert-butyl alcohol / 0.17 h
2.2: 0.25 h / Inert atmosphere
2.3: 25 h / 20 - 60 °C / Inert atmosphere
3.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate / toluene / 0.08 h
3.2: 48 h / 100 °C
With
bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; palladium diacetate; potassium carbonate; diisopropylamine; sodium t-butanolate;
In
water; toluene; tert-butyl alcohol;
1.2: Sonogashira coupling / 2.3: Huisgen cycloaddition;
DOI:10.1021/ic102338g
