(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Name:(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone
CAS No.:1597522-15-0
Molecular Formula:C₂₆H₂₂F₃N₅O₄
Molecular Weight:525.487
Hs Code.:

Synonyms:(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Chemical Property of (5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

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Technology Process of (5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

There total 8 articles about (5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1597527-77-9
5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

: 1597528-48-7
5-(S)-pyrrolidin-2-yl-3-(2-trifluoromethoxyphenyl)[1,2,4]oxadiazole

: 1597522-15-0
(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 1597522-15-0
(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / acetic acid; water / 2 h / 60 °C

2: sulfuric acid / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 160 °C / Irradiation

4: sodium hydroxide; water / methanol; tetrahydrofuran / 48 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; bromine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 61809-40-3
2-bromo-5-methoxy-4-methyl-benzoic acid

: 1597522-15-0
(5-methoxy-4-methyl-2-pyrimidin-2-ylphenyl)-{(S)-2-[3-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 160 °C / Irradiation

3: sodium hydroxide; water / methanol; tetrahydrofuran / 48 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;