5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

Base Information

Chemical Name:5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride
CAS No.:1597527-77-9
Molecular Formula:C₁₃H₁₂N₂O₃*ClH
Molecular Weight:280.711
Hs Code.:

Synonyms:5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

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Chemical Property of 5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

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Technology Process of 5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

There total 4 articles about 5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1597527-79-1
methyl 5-methoxy-4-methyl-2-(pyrimidin-2-yl)benzoate

: 1597527-77-9
5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

Guidance literature:: methyl 5-methoxy-4-methyl-2-(pyrimidin-2-yl)benzoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In water;
DOI:10.1002/cmdc.201900242

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 1597527-77-9
5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / acetic acid; water / 2 h / 60 °C

2: sulfuric acid / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 160 °C / Irradiation

4: sodium hydroxide; water / methanol; tetrahydrofuran / 48 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; bromine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetic acid;

Reference yield:

: 61809-40-3
2-bromo-5-methoxy-4-methyl-benzoic acid

: 1597527-77-9
5-methoxy-4-methyl-2-pyrimidin-2-ylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 160 °C / Irradiation

3: sodium hydroxide; water / methanol; tetrahydrofuran / 48 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;