Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃

Base Information

• Chemical Name: Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃
• CAS No.: 74085-68-0
• Molecular Formula: C₃₃H₄₀N₆O₈S
• Molecular Weight: 680.782

Synonyms:Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃

Chemical Property of Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃

Chemical Property:

Purity/Quality:

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Technology Process of Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃

There total 9 articles about Z-Tyr-D-Met(O)-Gly-Phe-NHNH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Z-Tyr-D-Met(O)-Gly-Phe-OEt (74085-67-9) → Z-Tyr-D-Met(O)-Gly-Phe-NHNH3 (74085-68-0)

Guidance literature:

With hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1248/cpb.29.3646

Reference yield:

CbzGly-L-PheOEt (3956-78-3) → Z-Tyr-D-Met(O)-Gly-Phe-NHNH3 (74085-68-0)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen / Pd-black / methanol

2: acetonitrile / Ambient temperature

3: 30percent agueous H₂O₂ / aq. HCl / 10 h / Ambient temperature

4: TFA / 20 h / Ambient temperature

5: TEA / acetonitrile

6: 85 percent / NH₂NH₂*H₂O / ethanol; dimethylformamide / 48 h / Ambient temperature

With TEA; hydrogen; dihydrogen peroxide; hydrazine hydrate; trifluoroacetic acid; palladium; In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.29.3646

Reference yield:

(L)-phenylalanine ethyl ester hydrochloride (3182-93-2) → Z-Tyr-D-Met(O)-Gly-Phe-NHNH3 (74085-68-0)

Guidance literature:

Multi-step reaction with 7 steps

1: TEA / acetonitrile / Ambient temperature

2: hydrogen / Pd-black / methanol

3: acetonitrile / Ambient temperature

4: 30percent agueous H₂O₂ / aq. HCl / 10 h / Ambient temperature

5: TFA / 20 h / Ambient temperature

6: TEA / acetonitrile

7: 85 percent / NH₂NH₂*H₂O / ethanol; dimethylformamide / 48 h / Ambient temperature

With TEA; hydrogen; dihydrogen peroxide; hydrazine hydrate; trifluoroacetic acid; palladium; In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.29.3646

upstream raw materials:

Z-Tyr-D-Met(O)-Gly-Phe-OEt

ethyl glycyl-L-phenylalaninate

CbzGly-L-PheOEt

(L)-phenylalanine ethyl ester hydrochloride

Downstream raw materials:

Tyr-D-Met(O)-Gly-Phe-NH-NH₂

[(S)-1-[(R)-1-({[(S)-1-Benzyl-2-(N'-hexanoyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-3-methanesulfinyl-propylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester

[(S)-1-[(R)-1-({[(S)-1-Benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-3-methanesulfinyl-propylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester

(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N-{[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-4-methanesulfinyl-butyramide

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