2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

Base Information

Chemical Name:2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid
CAS No.:1280293-77-7
Molecular Formula:C₂₃H₂₂F₃N₅O₄
Molecular Weight:489.454
Hs Code.:

Synonyms:2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

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Chemical Property of 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

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Technology Process of 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

There total 9 articles about 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1280197-96-7
ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

: 1280293-77-7
2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

Guidance literature:: ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate; With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 50 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=6;
DOI:10.1021/jm101340q

Reference yield:

: 1280197-69-4
3-(piperazin-1-yl)-5-nitro-7-(trifluoromethyl)quinoline

: 1280293-77-7
2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 0 °C / Inert atmosphere

2.1: iron; ammonium chloride / ethanol; water / Reflux

3.1: ethanol / Inert atmosphere; Reflux

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 50 °C

5.2: pH 6

With sodium tetrahydroborate; lithium hydroxide monohydrate; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; ethanol; water; acetone;
DOI:10.1021/jm101340q

Reference yield:

: C₁₈H₂₁F₃N₄O₂

: 1280293-77-7
2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 50 °C

3.2: pH 6

With sodium tetrahydroborate; lithium hydroxide monohydrate; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jm101340q