ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

Base Information

Chemical Name:ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate
CAS No.:1280197-96-7
Molecular Formula:C₂₅H₂₆F₃N₅O₄
Molecular Weight:517.508
Hs Code.:

Synonyms:ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

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Chemical Property of ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

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Technology Process of ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

There total 8 articles about ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₄F₃N₅O₄

: 1280197-96-7
ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm101340q

Reference yield:

: 1280197-69-4
3-(piperazin-1-yl)-5-nitro-7-(trifluoromethyl)quinoline

: 1280197-96-7
ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 0 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / Reflux

3: ethanol / Inert atmosphere; Reflux

4: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; iron; potassium carbonate; ammonium chloride; In ethanol; water; acetone;
DOI:10.1021/jm101340q

Reference yield:

: C₁₈H₂₁F₃N₄O₂

: 1280197-96-7
ethyl 2-(4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Inert atmosphere; Reflux

2: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; In ethanol;
DOI:10.1021/jm101340q