(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

Base Information

Chemical Name:(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal
CAS No.:83021-10-7
Molecular Formula:C₁₈H₃₂O₂Si
Molecular Weight:308.536
Hs Code.:

Synonyms:(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

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Chemical Property of (-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

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Technology Process of (-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

There total 5 articles about (-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 83021-09-4
(-)-3-<(R)-4-(t-Butyl)dimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propen-1-ol

: 83021-10-7
(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

Guidance literature:: With manganese(IV) oxide; In ethyl acetate; for 0.5h; Ambient temperature;
DOI:10.1002/hlca.19820650323

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 83021-10-7
(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

Guidance literature:: Multi-step reaction with 4 steps

1: 6.5 g / 4-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) NaOH, Br₂; 2.) Na₂S₂O₅ / 1.) water, dioxane, 1 h, 0 deg C; 2.) water

3: 85 percent / LiAlH₄ / diethyl ether / Ambient temperature

4: 82 percent / MnO₂ / ethyl acetate / 0.5 h / Ambient temperature

With dmap; manganese(IV) oxide; sodium metabisulfite; sodium hydroxide; lithium aluminium tetrahydride; bromine; triethylamine; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1002/hlca.19820650323

Reference yield:

: 83021-07-2
(S,E)-4-[4-(tert-butyldimethylsilyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]but-3-en-2-one

: 83021-10-7
(-)-<(R)-4-t-Butyldimethylsilyloxy-2,6,6-trimethyl-1-cyclohexen-1-yl>propenal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOH, Br₂; 2.) Na₂S₂O₅ / 1.) water, dioxane, 1 h, 0 deg C; 2.) water

2: 85 percent / LiAlH₄ / diethyl ether / Ambient temperature

3: 82 percent / MnO₂ / ethyl acetate / 0.5 h / Ambient temperature

With manganese(IV) oxide; sodium metabisulfite; sodium hydroxide; lithium aluminium tetrahydride; bromine; In diethyl ether; ethyl acetate;
DOI:10.1002/hlca.19820650323