[(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester
• CAS No.: 1456722-35-2
• Molecular Formula: C₂₆H₃₃NO₇
• Molecular Weight: 471.551
• Mol file: 1456722-35-2.mol

Synonyms:[(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester

Chemical Property of [(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester

There total 1 articles about [(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) + (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate (1428650-45-6) → [(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester (1456722-35-2)

Guidance literature:

2-(2-bromophenyl)-1,3-dioxolan; With n-butyllithium; In hexane; toluene; at 0 ℃; for 0.5h; Inert atmosphere;

(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate; In hexane; toluene; at 0 - 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1016/j.tet.2013.08.042

Reference yield: 85.0%

[(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester (1456722-35-2) → {(R)-3-(3,4-dimethoxy-phenyl)-1-[(2-[1,3]-di-oxolan-2-yl-phenyl)-hydroxymethyl]-propyl}-carbamic acid

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2013.08.042

Reference yield:

[(R)-3-(3,4-dimethoxy-phenyl)-1-(2-[1,3]dioxolan-2-ylbenzoyl)-propyl]-carbamic acid tert-butyl ester (1456722-35-2) → (6aR,12bR)-10,11-dimethoxy-6-(4-nitro benzene sulfonyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine (1456722-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; ethanol / 2 h / 0 - 20 °C / Inert atmosphere

2: methanesulfonic acid / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

3: sodium tetrahydroborate; ethanol / 0.75 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; methanesulfonic acid; ethanol; triethylamine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.tet.2013.08.042

upstream raw materials:

2-(2-bromophenyl)-1,3-dioxolan

(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate

Downstream raw materials:

(6aR,12bR)-10,11-dimethoxy-6-(4-nitro benzene sulfonyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine