ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate

Base Information

• Chemical Name: ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate
• CAS No.: 1268500-92-0
• Molecular Formula: C₂₆H₂₈F₃NO₃S₂
• Molecular Weight: 523.64
• Mol file: 1268500-92-0.mol

Synonyms:ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate

Chemical Property of ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate

There total 5 articles about ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 2-bromoisobutyrate (600-00-0) + 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol (1268500-80-6) → ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate (1268500-92-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1002/ardp.201000189

Reference yield:

o-Hydroxyethylbenzene (90-00-6) → ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate (1268500-92-0)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; sodium bromide / methanol / 3 h / 0 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

4: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; bromine; caesium carbonate; sodium bromide; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1002/ardp.201000189

Reference yield:

3-ethyl-4-hydroxythiophenol → ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate (1268500-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

With caesium carbonate; In acetonitrile;

DOI:10.1002/ardp.201000189

upstream raw materials:

ethyl 2-bromoisobutyrate

2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol

o-Hydroxyethylbenzene

2-ethyl-4-thiocyanatophenol

Downstream raw materials:

2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid