2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol

Base Information

• Chemical Name: 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol
• CAS No.: 1268500-80-6
• Molecular Formula: C₂₀H₁₈F₃NOS₂
• Molecular Weight: 409.496
• Mol file: 1268500-80-6.mol

Synonyms:2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol

Chemical Property of 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol

There total 3 articles about 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-ethyl-4-hydroxythiophenol + 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (317318-97-1) → 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol (1268500-80-6)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ardp.201000189

Reference yield:

2-ethyl-4-thiocyanatophenol (99357-68-3) → 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol (1268500-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ardp.201000189

Reference yield:

o-Hydroxyethylbenzene (90-00-6) → 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol (1268500-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; sodium bromide / methanol / 3 h / 0 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; bromine; caesium carbonate; sodium bromide; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1002/ardp.201000189

upstream raw materials:

5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

o-Hydroxyethylbenzene

2-ethyl-4-thiocyanatophenol

Downstream raw materials:

ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate

2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}acetic acid

2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid