C₁₆H₁₈FNO₃

Base Information

• Chemical Name: C₁₆H₁₈FNO₃
• CAS No.: 959683-25-1
• Molecular Formula: C₁₆H₁₈FNO₃
• Molecular Weight: 291.322
• Mol file: 959683-25-1.mol

Synonyms:C₁₆H₁₈FNO₃

Chemical Property of C₁₆H₁₈FNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₈FNO₃

There total 2 articles about C₁₆H₁₈FNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-fluorophenylzinc chloride + tert-butyl 4-oxopyridine-1-carboxylate (332940-69-9) → C16H18FNO3 (959683-25-1)

Guidance literature:

tert-butyl 4-oxopyridine-1-carboxylate; With chlorobis(ethylene)rhodium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at -5 ℃; for 0.25h; Inert atmosphere;

4-fluorophenylzinc chloride; With chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules22050723

Reference yield: 41.0%

4-methoxypyridine (620-08-6,1232006-56-2) + di-tert-butyl dicarbonate (24424-99-5) + 4-flourophenylmagnesium bromide (352-13-6) → C16H18FNO3 (959683-25-1)

Guidance literature:

4-methoxypyridine; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.166667h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 9h;

DOI:10.1021/acs.orglett.5b02778

Reference yield:

C16H18FNO3 (959683-25-1) + tert-butyl((1-methoxybuta-1,3-dien-1-yl)oxy)dimethylsilane (119582-47-7) → C27H40FNO5Si + C27H40FNO5Si

Guidance literature:

With indium(III) triflate; In toluene; at -78 ℃; diastereoselective reaction;

DOI:10.1021/acs.orglett.5b02778

upstream raw materials:

4-methoxypyridine

di-tert-butyl dicarbonate

4-flourophenylmagnesium bromide

tert-butyl 4-oxopyridine-1-carboxylate

Refernces

• 1、 Guo, Fenghai,McGilvary, Matthew A.,Jeffries, Malcolm C.,Graves, Briana N.,Graham, Shekinah A.,Wu, Yuelin. "Rhodium(I)-complexes catalyzed 1,4-conjugate addition of arylzinc chlorides to N-boc-4-pyridone". . . Retrieved 2017/06/08.