Imidazo[1,2-c]quinazolin-5(3H)-one,2-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-2,6-dihydro-

Base Information

• Chemical Name: Imidazo[1,2-c]quinazolin-5(3H)-one,2-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-2,6-dihydro-
• CAS No.: 149847-76-7
• Molecular Formula: C₂₁H₂₂ClN₅O
• Molecular Weight: 395.892
• Mol file: 149847-76-7.mol

Synonyms:CK 53; CK53 (pharmaceutical)

Chemical Property of Imidazo[1,2-c]quinazolin-5(3H)-one,2-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-2,6-dihydro-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-c]quinazolin-5(3H)-one,2-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-2,6-dihydro-

There total 3 articles about Imidazo[1,2-c]quinazolin-5(3H)-one,2-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-2,6-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-allylureido)benzonitrile (122372-27-4) → CK 53 (149847-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / 28percent aq. NH₃ / ethanol / 0.25 h / Heating

2: 95 percent / NBS / tetrahydrofuran / 0.42 h / Ambient temperature

3: 67 percent / acetonitrile / 13 h / Heating

With ammonium hydroxide; N-Bromosuccinimide; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1021/jm00067a017

Reference yield:

3,4-dihydro-4-imino-2-allylquinazolin-2(1H)-one (122372-31-0) → CK 53 (149847-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NBS / tetrahydrofuran / 0.42 h / Ambient temperature

2: 67 percent / acetonitrile / 13 h / Heating

With N-Bromosuccinimide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00067a017

Reference yield:

anthranilic acid nitrile (1885-29-6) → CK 53 (149847-76-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / 48 h / Ambient temperature

2: 84 percent / 28percent aq. NH₃ / ethanol / 0.25 h / Heating

3: 95 percent / NBS / tetrahydrofuran / 0.42 h / Ambient temperature

4: 67 percent / acetonitrile / 13 h / Heating

With ammonium hydroxide; N-Bromosuccinimide; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1021/jm00067a017

upstream raw materials:

2-(3-allylureido)benzonitrile

3,4-dihydro-4-imino-2-allylquinazolin-2(1H)-one

anthranilic acid nitrile