1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

Base Information

• Chemical Name: 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea
• CAS No.: 1188906-54-8
• Molecular Formula: C₂₄H₂₅N₅O₅
• Molecular Weight: 463.493

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

Chemical Property:

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

There total 2 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea (1188906-55-9) + 6,7-dimethoxy-4-chloroquinazoline (13790-39-1) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea (1188906-54-8)

Guidance literature:

1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h;

6,7-dimethoxy-4-chloroquinazoline; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1016/j.bmcl.2011.07.019

Reference yield:

m-Hydroxyaniline (591-27-5) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea (1188906-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 50 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

2.2: 72 h / 20 °C

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.07.019

Reference yield: 42.0%

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea (1188906-54-8) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride (1188906-56-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Sonication;

upstream raw materials:

1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea

6,7-dimethoxy-4-chloroquinazoline

m-Hydroxyaniline

Downstream raw materials:

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

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