(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

Base Information

Chemical Name:(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester
CAS No.:420834-46-4
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

Synonyms:(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

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Chemical Property of (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

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Technology Process of (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

There total 11 articles about (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4S,5R)-2,2-Dimethyl-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-benzyl ester 5-((4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

: 420834-46-4
(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; atmospheric pressure;

Reference yield:

: 132201-32-2,161453-08-3,949459-75-0,521059-43-8
(2R,3S)-3-phenylisoserine hydrochloride

: 420834-46-4
(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / SOCl₂ / 0 °C

2: NaHCO₃

3: pyridinium p-toluenesulfonate

4: LiOH / methanol

5: DCC; DMAP / CH₂Cl₂ / 0.25 h

6: H₂ / Pd/C / methanol / 20 °C / atmospheric pressure

With dmap; lithium hydroxide; thionyl chloride; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

: 156857-28-2
(4R,4aR,7aS,8S)-4,8-dihydroxy-4,4a,5,6,7,7a,8,9-octahydro-6,6,8-trimethylazulene<5,6-c>furan

: 420834-46-4
(2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aR,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC; DMAP / toluene / 20 °C

2: Zn; AcOH / methanol / 20 °C

With dmap; acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; toluene;