(2R,3S)-3-phenylisoserine hydrochloride

Base Information

Chemical Name:(2R,3S)-3-phenylisoserine hydrochloride
CAS No.:132201-32-2
Molecular Formula:C9H12ClNO3
Molecular Weight:217.652
Hs Code.:2942000000
DSSTox Substance ID:DTXSID10564249
Mol file:132201-32-2.mol

Synonyms:(2R,3S)-3-phenylisoserine hydrochloride;132201-32-2;(2R,3S)-3-Phenylisoserine HCl;(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid hydrochloride;(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoic acid;hydrochloride;MFCD09750971;(2r,3s)-3-amino-2-hydroxy-3-phenyl-propanoic acid hydrochloride;[(1S,2R)-2-carboxy-2-hydroxy-1-phenylethyl]azanium;chloride;(2R,3S)-3-amino-2-hydroxy-3-phenyl-propanoic acid;Benzenepropanoic acid, beta-amino-alpha-hydroxy-, hydrochloride (1:1), (alphaR,betaS)-;(2R,3S)-3-Phenylisoserine hydrochloride;Benzenepropanoic acid, beta-amino-alpha-hydroxy-, hydrochloride, (alphaR,betaS)- (9CI);Benzenepropanoic acid, beta-amino-alpha-hydroxy-, hydrochloride, [R-(R*,S*)]-;(2R,3S)-3-Phenylisoserine hydrochloride salt;(2R,3S)-3-Phenylisoserinehydrochloride;H-Ise(3-Phenyl)-OH.HCl;SCHEMBL3184809;DTXSID10564249;CHEBI:228837;AMY14655;HY-N2378;AKOS015888978;AC-1998;CS-W023105;DS-1890;(2R,3S)-3-Phenylisoserine hydrochloride, 97%;EN300-7386027;A806393;(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid--hydrogen chloride (1/1)

Suppliers and Price of (2R,3S)-3-phenylisoserine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,3S)-3-PhenylisoserineHydrochloride
1g
$ 50.00

SynQuest Laboratories
(2R,3S)-3-Phenylisoserine hydrochloride
1 g
$ 280.00

SynQuest Laboratories
(2R,3S)-3-Phenylisoserine hydrochloride
5 g
$ 840.00

Matrix Scientific
(2R,3S)-3-Phenylisoserinehydrochloride >95%
5g
$ 972.00

Matrix Scientific
(2R,3S)-3-Phenylisoserinehydrochloride >95%
1g
$ 324.00

Labseeker
(2R,3S)-3-PhenylisoserineHydrochloride 95
5g
$ 367.00

DC Chemicals
(2R,3S)-3-Phenylisoserinehydrochloride >98%
20 mg
$ 280.00

Crysdot
(2R,3S)-3-Phenylisoserinehydrochloride 97%
100g
$ 624.00

Crysdot
(2R,3S)-3-Phenylisoserinehydrochloride 97%
25g
$ 248.00

Chemenu
(2R,3S)-3-Phenylisoserinehydrochloride 97%
10g
$ 128.00

Total 108 raw suppliers

Chemical Property of (2R,3S)-3-phenylisoserine hydrochloride

Chemical Property:

Vapor Pressure:3.98E-07mmHg at 25°C
Melting Point:222-224 ºC (dec.)
Boiling Point:400.3oC at 760 mmHg
Flash Point:195.9oC
PSA：83.55000
LogP:1.63420
Storage Temp.:Inert atmosphere,Room Temperature
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:217.0505709
Heavy Atom Count:14
Complexity:178

Purity/Quality:

99% ^*data from raw suppliers

(2R,3S)-3-PhenylisoserineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C(C(=O)O)O)N.Cl
Isomeric SMILES:C1=CC=C(C=C1)[C@@H]([C@H](C(=O)O)O)N.Cl
General Description (2R,3S)-3-Phenylisoserine hydrochloride is a key chiral intermediate for the synthesis of the Taxol (paclitaxel) C-13 side chain, characterized by high enantiomeric purity (ee ≥ 99%). It can be synthesized via chemo-enzymatic routes, such as Burkholderia cepacia-catalyzed enantioselective O-acylation followed by acidic hydrolysis, or through diastereoselective chemical methods involving the reaction of dihydrodihydroxycinnamic acids with nitriles. (2R,3S)-3-Phenylisoserine hydrochloride exhibits syn-β-amino-α-hydroxypropionic acid structure and is crucial for the efficient large-scale production of Taxol derivatives.

Technology Process of (2R,3S)-3-phenylisoserine hydrochloride

There total 29 articles about (2R,3S)-3-phenylisoserine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%