tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate
CAS No.:1314894-07-9
Molecular Formula:C₂₃H₂₆ClF₂N₅O₃S
Molecular Weight:526.007
Hs Code.:

Synonyms:tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

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Chemical Property of tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

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Technology Process of tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

There total 2 articles about tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314893-92-9
3-bromo-6-chloropyrazolo[1,5-a]pyrimidine

: 1314894-07-9
tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 3 h / 60 °C

3.1: thionyl chloride / 0.5 h / 60 °C

3.2: 0.5 h / 20 °C

With thionyl chloride; water; sodium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1314894-03-5
methyl 4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophene-2-carboxylate

: 1314894-07-9
tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / tetrahydrofuran; methanol / 3 h / 60 °C

2.1: thionyl chloride / 0.5 h / 60 °C

2.2: 0.5 h / 20 °C

With thionyl chloride; water; potassium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1314894-07-9
tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate

: 1314893-26-9
N-((1R,6R)-6-amino-2,2-difluorocyclohexyl)-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophene-2-carboxamide

Guidance literature:: tert-butyl (1R,2R)-2-({[4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methylthiophen-2-yl]carbonyl}amino)-3,3-difluorocyclohexylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water;