1314893-26-9Relevant articles and documents
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties
Sloman, David L.,Noucti, Njamkou,Altman, Michael D.,Chen, Dapeng,Mislak, Andrea C.,Szewczak, Alexander,Hayashi, Mansuo,Warren, Lee,Dellovade, Tammy,Wu, Zhenhua,Marcus, Jacob,Walker, Deborah,Su, Hua-Poo,Edavettal, Suzanne C.,Munshi, Sanjeev,Hutton, Michael,Nuthall, Hugh,Stanton, Matthew G.
, p. 4362 - 4366 (2016/08/18)
Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. This manuscript outlines efforts to optimize a pyrazolopyrimidine series of MARK in