1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin

Base Information

• Chemical Name: 1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin
• CAS No.: 131657-53-9
• Molecular Formula: C₁₄H₂₀N₂O₂S
• Molecular Weight: 280.391
• Mol file: 131657-53-9.mol

Synonyms:1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin

Chemical Property of 1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin

There total 1 articles about 1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-methyl-2-azepanone (2556-73-2) + Tosyl isocyanate (4083-64-1) → 1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin (131657-53-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jo00004a035

Reference yield:

1-methyl-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepin (131657-53-9) + benzaldehyde (100-52-7) → rel-(3S,1'S)-1-methyl-3-(1'-hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepine (131657-75-5,131657-76-6) + rel-(3S,1'R)-1-methyl-3-(1'-hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepine (131657-75-5,131657-76-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00004a035

upstream raw materials:

1-methyl-2-azepanone

Tosyl isocyanate

Downstream raw materials:

rel-(3S,1'S)-1-methyl-3-(1'-hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepine

rel-(3S,1'R)-1-methyl-3-(1'-hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)hexahydroazepine

Refernces