4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

Base Information

Chemical Name:4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid
CAS No.:1050950-67-8
Molecular Formula:C₁₇H₁₂N₂O₅S
Molecular Weight:356.359
Hs Code.:

Synonyms:4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

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Chemical Property of 4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

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Technology Process of 4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

There total 5 articles about 4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 875456-04-5
methyl 4-(5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl benzoate

: 1050950-67-8
4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

Guidance literature:: methyl 4-(5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl benzoate; With lithium hydroxide; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1021/jm300309a

Reference yield:

: 94-53-1
Piperonylic acid

: 1050950-67-8
4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 13 h / 0 - 50 °C

2: hydrazine hydrate / ethanol / 48 h / Reflux

3: triethylamine / ethanol / Reflux; Inert atmosphere

4: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

5: lithium hydroxide / tetrahydrofuran / 60 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300309a

Reference yield:

: 22026-39-7
benzo[d][1,3]dioxole-5-carbohydrazide

: 1050950-67-8
4-((5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-ylthio)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / Reflux; Inert atmosphere

2: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran / 60 °C / Inert atmosphere

With triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300309a