2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

Base Information

Chemical Name:2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride
CAS No.:1152274-48-0
Molecular Formula:C₃₂H₃₀F₂N₃O₅*Cl
Molecular Weight:610.057
Hs Code.:

Synonyms:2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

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Chemical Property of 2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

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Technology Process of 2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

There total 14 articles about 2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₀F₂N₃O₅⁽¹⁺⁾*I^(1-)

: 1152274-48-0
2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 1h;

Reference yield:

: 862574-88-7
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid

: 1152274-48-0
2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C

2: triethylamine / dichloromethane / 18 h / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C

4: dichloromethane / 3.5 h / 20 °C

5: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

6: dichloromethane / 20 °C

7: acetone / 1.5 h

8: hydrogenchloride / methanol / 1 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 33070-32-5
5-bromo-2,2-difluoro-2H-1,3-benzodioxole

: 1152274-48-0
2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride

Guidance literature:: Multi-step reaction with 14 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 15 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: thionyl chloride / dichloromethane / 0 - 20 °C

4.1: dimethyl sulfoxide / 20 °C

5.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 70 °C

6.1: sodium hydroxide; water / 2.5 h / Heating / reflux

7.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C

8.1: triethylamine / dichloromethane / 18 h / 20 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C

10.1: dichloromethane / 3.5 h / 20 °C

11.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

12.1: dichloromethane / 20 °C

13.1: acetone / 1.5 h

14.1: hydrogenchloride / methanol / 1 h / 60 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;