N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

Base Information

Chemical Name:N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide
CAS No.:1357390-44-3
Molecular Formula:C₂₇H₂₅F₂N₅O₂
Molecular Weight:489.525
Hs Code.:

Synonyms:N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

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Technology Process of N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

There total 5 articles about N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1357390-43-2
N'-(5-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxopiperidin-1-yl]ethylcarbamoyl}pyridin-2-yl)hydrazinecarboxylic acid tert-butyl ester

: 1357390-44-3
N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

Guidance literature:: With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 5h;
DOI:10.1111/j.1747-0285.2011.01271.x

Reference yield:

: 342808-41-7
3,5-bis-(2-fluorobenzylidene)-4-piperidone acetic acid

: 1357390-44-3
N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

3: hydrogenchloride / dichloromethane; water / 5 h / 20 °C

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1111/j.1747-0285.2011.01271.x

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1357390-44-3
N-{2-[3,5-bis-(2-fluorobenzylidene)-4-oxo-piperidin-1-yl]-ethyl}-6-hydrazinonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 48 h / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

4: hydrogenchloride / dichloromethane; water / 5 h / 20 °C

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1111/j.1747-0285.2011.01271.x